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Tuesday, December 15, 2015

Major Study: Antidepressants During Pregnancy Doubles The Risk Of Autism

Antidepressants during pregnancy doubles the risk of autism

Major research suggests that taking antidepressants during the second or third trimester of pregnancy doubles the risk that children will develop autism

Taking antidepressants during pregnancy almost doubles the risk of children developing autism, a major study has found.
The study on more than 140,000 pregnant women found that taking drugs such as Prozac and Seroxat during the second and third trimester significantly increases the chance of such conditions.
About 20,000 women a year take antidepressants during pregnancy
Researchers said the reasons were unknown but that it was “biologically plausible" that the medication could affect the development of the brain in the womb at a critical stage.
Current NHS advice suggests such drugs should be avoided in pregnancy – because they have been linked to miscarriage and to health problems for the unborn child.
However, doctors are advised to continue prescribing the drugs if they believe the risks of depression outweigh other considerations.

As a result about 20,000 Canadian women a year take antidepressants.
Medication nation: 46 m prescriptions for antidepressants were dispensed in Britain last year
The study found an increase in the incidence of autism among children whose mothers took antidepressants during the second and third trimester of their pregnancy

The study by the University of Montreal followed 145,456 pregnancies and children up to the age of 10.
It found 1,054 children were diagnosed with autism at an average age of 4½ years.
The chance of such a diagnosis was increased by 87 per cent among offspring of women who took anti-depressants in the last six months of pregnancy.
Women should not stop their medication suddenly ... Antidepressants definitely have their place
Prof Ian Jones, Director, National Centre for Mental Health
Previous studies have found conflicting evidence linking antidepressants in pregnancy with autism in children.
In 2011, a small study in Calfornia suggested that use of SSRIs during pregnancy could double the risk of autism. But two years later, a larger Danish study suggested such risks were almost eliminated if researchers adjusted for the presence of underlying depression in the mother.
Researcher Professor Anick Bérard said: "The variety of causes of autism remain unclear, but studies have shown that both genetics and environment can play a role.
"Our study has established that taking antidepressants during the second or third trimester of pregnancy almost doubles the risk that the child will be diagnosed with autism by age seven, especially if the mother takes selective serotonin reuptake inhibitors, often known by its acronym SSRIs."
Taking antidepressants during pregnancy doubles risk of children developing autism, according to a major study
The National Centre for Medical Health says it is unclear whether the increased risk of autism stemmed from the medication, or the disorders for which it was prescribed
She said it the inhibition of serotonin could be having a negative impact on brain development in the womb.
"It is biologically plausible that anti-depressants are causing autism if used at the time of brain development in the womb, as serotonin is involved in numerous pre- and postnatal developmental processes, including cell division, the migration of neuros, cell differentiation and synaptogenesis - the creation of links between brain cell,” the scientist said.
Prof Ian Jones, Director, National Centre for Mental Health, Cardiff University, said: “This paper addresses an important issue for many women who face difficult decisions about starting or continuing antidepressant medication in pregnancy.”
He said the findings were consistent with other studies.
However, he said it remained unclear whether the increased risk of autism stemmed from the medication, or the disorders for which it was prescribed.
Those on antidepressants should consider whether to come off them if they were thinking of starting a family, but discuss such decisions with their doctors, he said.
“Women should not stop their medication suddenly and, if they are concerned about continuing the antidepressant in pregnancy, they should discuss the options with their doctor. Antidepressants definitely have their place,” he said.
Prof Seena Fazel, Professor of Forensic Psychiatry, University of Oxford, said the study had limitations, as it did not fully account for differences in the backgrounds of the different groups of women in the study.

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